Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | PRKX | P51817 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.40 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.40 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.40 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.40 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29822879 | 1.00 | ROCK1 (0.40) | ROCK1ROCK2DYRK3PRKACARPS6KB1 | |
| SCHEMBL30490858 | 1.00 | ROCK1 (0.40) | ROCK1ROCK2DYRK3PRKACARPS6KB1 | |
| SCHEMBL24675715 | 1.00 | ROCK1 (0.40) | ROCK1ROCK2DYRK3PRKACARPS6KB1 | |
| SCHEMBL25410186 | 0.91 | ROCK1 (0.41) | ROCK1ROCK2DYRK3PRKACARPS6KB1 | |
| SCHEMBL25410190 | 0.91 | ROCK1 (0.41) | ROCK1ROCK2DYRK3PRKACARPS6KB1 | |
| SCHEMBL24674913 | 0.90 | POLB (0.41) | ROCK1ROCK2DYRK3PRKACARPS6KB1 | |
| SCHEMBL29823058 | 0.89 | PFKFB3 (0.45) | ROCK1ROCK2DYRK3PRKACARPS6KB1 | |
| SCHEMBL24674842 | 0.87 | PPARA (0.46) | ROCK1ROCK2DYRK3PRKACARPS6KB1 | |
| SCHEMBL29822969 | 0.87 | PPARA (0.46) | ROCK1ROCK2DYRK3PRKACARPS6KB1 | |
| SCHEMBL24675472 | 0.87 | ROCK1 (0.41) | ROCK1ROCK2DYRK3PRKACARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129564-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | disclosed |