SCHEMBL25829310

SCHEMBL25829310

CC(C)(C)OC(=O)Nc1cc(F)c(I)c(F)c1F

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 1/20 0.41
RXFP1 Q9HBX9 1/20 0.38
KCNQ4 P56696 3/20 0.37
KCNQ5 Q9NR82 3/20 0.37
BRAF P15056 1/20 0.36
LMNA P02545 1/20 0.35
POLB P06746 1/20 0.35
AAK1 Q2M2I8 2/20 0.35
BRD9 Q9H8M2 1/20 0.34
SYK P43405 1/20 0.34
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA9 Q16790 1/20 0.33
METAP1 P53582 1/20 0.33
CNR2 P34972 1/20 0.33
TRPA1 O75762 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6124200 0.86 CYP17A1 (0.43) CYP17A1RXFP1KCNQ4KCNQ5BRAF
SCHEMBL25863098 0.83 CYP17A1 (0.42) CYP17A1RXFP1KCNQ4KCNQ5BRAF
SCHEMBL25829859 0.82 CYP17A1 (0.41) CYP17A1RXFP1KCNQ4KCNQ5BRAF
SCHEMBL29021688 0.81 CYP17A1 (0.39) CYP17A1RXFP1KCNQ4KCNQ5BRAF
SCHEMBL25830504 0.81 CYP17A1 (0.39) CYP17A1RXFP1KCNQ4KCNQ5BRAF
SCHEMBL4621173 0.80 CYP17A1 (0.42) CYP17A1RXFP1KCNQ4KCNQ5BRAF
SCHEMBL29178873 0.80 EGLN2 (0.42) CYP17A1RXFP1SYKCA12CA1
SCHEMBL30937702 0.79 CYP17A1 (0.40) CYP17A1RXFP1KCNQ4KCNQ5BRAF
SCHEMBL25829763 0.79 CYP17A1 (0.42) CYP17A1RXFP1KCNQ4KCNQ5BRAF
SCHEMBL14725520 0.79 CYP17A1 (0.48) CYP17A1RXFP1KCNQ4KCNQ5BRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023137007-A1 PROCESSES FOR THE PREPARATION OF 4,6,7-TRIFLUORO-1H-INDOLE-2-CARBOXYLIC ACID ENANTA PHARMACEUTICALS, INC. (US) 2023-07-20 WO disclosed