SCHEMBL25830932

CC(=O)N[C@@H](C(=O)N[C@H](C)C(=O)N[C@H](Cc1c[nH]c2cc(F)ccc12)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)NC1(C)CCCCCCCCC(C)(C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](C)C(=O)N[C@H](C)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](Cc2ccc(C(F)(F)F)cc2)NC1=O)[C@H](C)O

nearest known ligand 0.68

Predicted protein targets (top 6)

	gene	UniProt	supporting neighbours	confidence
▸	MDM2	Q00987	17/20	0.68

▸	MDM4	O15151	13/20	0.68

▸	TP53	P04637	1/20	0.67

▸	PCSK9	Q8NBP7	2/20	0.64

▸	GALR2	O43603	1/20	0.51

▸	GALR1	P47211	1/20	0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL25831288	0.99	MDM2 (0.67)	MDM2MDM4TP53PCSK9
SCHEMBL25831207	0.93	MDM2 (0.61)	MDM2MDM4TP53PCSK9GALR2
SCHEMBL25831036	0.83	MDM2 (0.57)	MDM2MDM4TP53PCSK9
SCHEMBL25831123	0.83	MDM2 (0.57)	MDM2MDM4TP53PCSK9
Sulanemadlin SCHEMBL29372019	0.80	MDM2 (1.00)	MDM2MDM4TP53PCSK9
SCHEMBL16866604	0.78	MDM2 (0.79)	MDM2MDM4TP53PCSK9GALR2
SCHEMBL16866605	0.77	MDM2 (0.79)	MDM2MDM4TP53PCSK9GALR2
SCHEMBL16866602	0.76	MDM2 (0.69)	MDM2MDM4TP53PCSK9
SCHEMBL16866608	0.74	MDM2 (0.74)	MDM2MDM4TP53PCSK9GALR2
SCHEMBL19406552	0.71	MDM2 (0.76)	MDM2MDM4TP53PCSK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2023107353-A2	P53 PEPTIDOMIMETIC MACROCYCLES	MERCK SHARP & DOHME LLC (US)	2023-06-15	—	—	WO	disclosed