Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23692294 | 0.81 | TACR1 (0.35) | TACR1POLBTRPV1CHRM2CHRM4 | |
| SCHEMBL25833599 | 0.75 | MEN1 (0.31) | KMT2AMEN1 | |
| SCHEMBL21122067 | 0.69 | BACE1 (0.41) | TACR1POLBSLC13A5CHRM2CHRM4 | |
| SCHEMBL28931092 | 0.67 | GBA1 (0.35) | TACR1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL25166912 | 0.67 | CHRM2 (0.32) | TACR1POLBTRPV1SLC13A5CHRM2 | |
| SCHEMBL31509769 | 0.67 | TRPV1 (0.31) | TACR1TRPV1CHRM2CHRM4CHRM5 | |
| SCHEMBL25834986 | 0.66 | ESR1 (0.36) | POLBHSD17B1SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL21121863 | 0.65 | KDM4E (0.41) | TRPV1KMT2AMEN1SMN1; SMN2KDM4E | |
| SCHEMBL15966092 | 0.65 | KDM4E (0.39) | POLBHSD17B1SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL23084662 | 0.65 | CHRM2 (0.33) | POLBTRPV1CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4209483-A1 | PRODRUG MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2023-07-12 | — | — | EP | disclosed |