Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.47 |
| ▸ | PDE2A | O00408 | 8/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11922289 | 0.81 | PDE3B (0.54) | PDE3BPDE3APDE2AADORA2AADORA2B | |
| SCHEMBL15221682 | 0.79 | PDE3B (0.47) | PDE3BPDE3APDE2AADORA2AADORA2B | |
| SCHEMBL1585845 | 0.79 | HSD17B10 (0.53) | PDE3BPDE3APDE2AADORA2AADORA2B | |
| SCHEMBL29705394 | 0.79 | HSD17B10 (0.53) | PDE3BPDE3APDE2AADORA2AADORA2B | |
| SCHEMBL17813540 | 0.77 | PDE3B (0.45) | PDE3BPDE3APDE2AADORA2AADORA2B | |
| SCHEMBL28523335 | 0.76 | PDE3B (0.44) | PDE3BPDE3APDE2AADORA2AADORA2B | |
| SCHEMBL2207001 | 0.74 | GRIN1 (0.60) | PDE3BPDE3APDE2AADORA2AADORA2B | |
| SCHEMBL11238693 | 0.73 | PDE3B (0.59) | PDE3BPDE3APDE2A | |
| SCHEMBL12830376 | 0.72 | PDE3B (0.47) | PDE3BPDE3APDE2AADORA2AADORA2B | |
| SCHEMBL28522267 | 0.72 | PDE3B (0.41) | PDE3BPDE3APDE2AADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023131122-A1 | FUSED RING-SUBSTITUTED SIX-MEMBERED HETEROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 劲方医药科技(上海)有限公司 | 2023-07-13 | — | — | WO | disclosed |