Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 18/20 | 0.80 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.80 |
| ▸ | AURKA | O14965 | 1/20 | 0.80 |
| ▸ | NEK2 | P51955 | 1/20 | 0.63 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31173516 | 1.00 | AXL (0.80) | AXLAURKBAURKANEK2PTK2 | |
| SCHEMBL25838418 | 0.89 | AXL (0.66) | AXLAURKBAURKANEK2PTK2 | |
| Dubermatinib SCHEMBL12813478 | 0.89 | AXL (1.00) | AXLAURKBAURKANEK2PTK2 | |
| Dubermatinib SCHEMBL29394359 | 0.89 | AXL (1.00) | AXLAURKBAURKANEK2PTK2 | |
| SCHEMBL25837702 | 0.88 | AXL (0.80) | AXLAURKBAURKANEK2PTK2 | |
| SCHEMBL25837786 | 0.86 | AXL (0.83) | AXLAURKBAURKANEK2PTK2 | |
| SCHEMBL25837701 | 0.86 | AXL (0.83) | AXLAURKBAURKANEK2PTK2 | |
| SCHEMBL31173499 | 0.86 | AXL (0.83) | AXLAURKBAURKANEK2PTK2 | |
| SCHEMBL22872055 | 0.83 | AXL (0.80) | AXLAURKBAURKANEK2PTK2 | |
| Dubermatinib SCHEMBL29814119 | 0.83 | AXL (0.87) | AXLAURKBAURKANEK2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023134582-A1 | PYRIMIDINE-2,4-DIAMINE DERIVATIVES AS WELL AS PREPARATION METHOD THEREFOR AND USE THEREOF | 上海立森印迹医药技术有限公司 | 2023-07-20 | — | — | WO | disclosed |