SCHEMBL25844122

SCHEMBL25844122

COc1cc(-c2cc(C)c(=O)n(C)c2)cc(OC)c1CN1CCN(C(C)C)CC1

nearest known ligand 0.67

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 19/20 0.67
BRD9 Q9H8M2 9/20 0.67
BRD2 P25440 3/20 0.58
BRD7 Q9NPI1 3/20 0.58
TLR4 O00206 1/20 0.38
TLR8 Q9NR97 1/20 0.38
BAZ2A Q9UIF9 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19869729 0.89 BRD4 (0.73) BRD4BRD9BRD2BRD7
SCHEMBL19869715 0.84 BRD4 (0.70) BRD4BRD9BRD2BRD7TLR4
SCHEMBL25091955 0.83 BRD9 (0.58) BRD4BRD9BRD2BRD7
SCHEMBL19857621 0.81 BRD4 (1.00) BRD4BRD9BRD2BRD7
SCHEMBL23798056 0.80 BRD4 (0.60) BRD4BRD9BRD2BRD7
SCHEMBL19869712 0.80 BRD4 (1.00) BRD4BRD9BRD2BRD7BAZ2A
SCHEMBL19869806 0.78 BRD4 (0.78) BRD4BRD9BRD2BRD7
SCHEMBL21224468 0.77 BRD4 (0.78) BRD4BRD9BRD2BRD7
SCHEMBL25091959 0.77 BRD9 (0.43) BRD4BRD9BRD2BRD7
SCHEMBL25844080 0.77 BRD9 (0.46) BRD4BRD9BRD2BRD7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11691972-B2 Compounds for targeted degradation of BRD9 C4 THERAPEUTICS, INC. (US) 2023-07-04 US disclosed
US-11691972-B2 Compounds for targeted degradation of BRD9 C4 THERAPEUTICS, INC. (US) 2023-07-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11691972-B2 Compounds for targeted degradation of BRD9 BRD9, BRD1, BRWD1 BRD4 17/4885BRD9 1/4885BRD2 6/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.