Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CTSC | P53634 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1706301 | 0.90 | SMN1; SMN2 (0.51) | MAPTSMN1; SMN2MEN1KMT2ARAB9A | |
| Hydrochloric Acid SCHEMBL13517466 | 0.89 | SMN1; SMN2 (0.50) | MAPTSMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL1706249 | 0.81 | MAPT (0.67) | MAPTSMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL1702525 | 0.78 | IGF1R (0.53) | MAPTMEN1KMT2ALMNAKDM4E | |
| SCHEMBL1702147 | 0.78 | MAPT (0.46) | MAPTSMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL22134947 | 0.77 | KDM1A (0.49) | MAPTSMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL1702502 | 0.76 | KDM4E (0.54) | MAPTSMN1; SMN2KMT2ARAB9ANPC1 | |
| SCHEMBL22116277 | 0.74 | CTSC (0.59) | MAPTSMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL29569079 | 0.74 | MAPT (0.57) | MAPTMEN1KMT2ANPC1GAA | |
| SCHEMBL12993921 | 0.74 | MAPT (0.57) | MAPTMEN1KMT2ANPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4215196-A1 | COMBINATION OF 8-CHLORO-N-(4-(TRIFLUOROMETHOXY)PHENYL)QUINOLIN-2-AMINE AND ITS DERIVATIVES WITH A JAK INHIBITOR | ABIVAX (FR) | 2023-07-26 | — | — | EP | disclosed |