Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24838817 | 0.93 | KMT2A (0.42) | KMT2ASMN1; SMN2CHRM4ACHEHRH3 | |
| SCHEMBL178287 | 0.87 | SMN1; SMN2 (0.46) | KMT2ASMN1; SMN2ACHEHRH3 | |
| SCHEMBL12605203 | 0.84 | MEN1 (0.42) | KMT2AHRH3OPRM1OPRL1MEN1 | |
| Fluoride SCHEMBL29252276 | 0.84 | SMN1; SMN2 (0.45) | KMT2ASMN1; SMN2ACHEHRH3KDM4E | |
| SCHEMBL26329494 | 0.84 | OPRL1 (0.48) | KMT2ASMN1; SMN2CHRM4HRH3OPRM1 | |
| SCHEMBL27258578 | 0.83 | KMT2A (0.33) | KMT2ASMN1; SMN2HRH3MEN1 | |
| SCHEMBL13179268 | 0.83 | KMT2A (0.44) | KMT2ASMN1; SMN2CHRM4ACHEMEN1 | |
| SCHEMBL11919058 | 0.82 | KMT2A (0.56) | KMT2ASMN1; SMN2CHRM4ACHEOPRM1 | |
| SCHEMBL11919045 | 0.82 | KMT2A (0.56) | KMT2ASMN1; SMN2CHRM4ACHE | |
| SCHEMBL24865954 | 0.81 | KMT2A (0.42) | KMT2ASMN1; SMN2CHRM4ACHEHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023242598-A1 | BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION | AMPHISTA THERAPEUTICS LIMITED (GB) | 2023-12-21 | — | — | WO | disclosed |
| WO-2023242597-A1 | BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION | AMPHISTA THERAPEUTICS LIMITED (GB) | 2023-12-21 | — | — | WO | disclosed |
| WO-2023131167-A1 | COMPOUND FOR INHIBITING AND DEGRADING IRAK4, AND PHARMACEUTICAL COMPOSITION AND PHARMACEUTICAL APPLICATION THEREOF | 海思科医药集团股份有限公司 | 2023-07-13 | — | — | WO | disclosed |