Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 4/20 | 0.45 |
| ▸ | ESR1 | P03372 | 4/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.45 |
| ▸ | TOP1 | P11387 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HPSE | Q9Y251 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 4/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25852548 | 1.00 | HRAS (0.45) | HRASESR1ESR2TOP1MAPT | |
| SCHEMBL16062745 | 1.00 | HRAS (0.45) | HRASESR1ESR2TOP1MAPT | |
| SCHEMBL20485567 | 0.88 | HRAS (0.45) | HRASESR1ESR2TOP1MAPT | |
| SCHEMBL25857874 | 0.88 | HRAS (0.48) | HRASESR1ESR2TOP1MAPT | |
| SCHEMBL14002824 | 0.88 | HRAS (0.45) | HRASESR1ESR2TOP1MAPT | |
| SCHEMBL23627239 | 0.88 | HRAS (0.48) | HRASESR1ESR2TOP1MAPT | |
| SCHEMBL5467775 | 0.88 | HRAS (0.45) | HRASESR1ESR2TOP1MAPT | |
| SCHEMBL12514045 | 0.85 | P2RY12 (0.44) | HRASESR1ESR2TOP1MAPT | |
| SCHEMBL21180775 | 0.85 | P2RY12 (0.44) | HRASESR1ESR2TOP1MAPT | |
| SCHEMBL26004856 | 0.85 | P2RY12 (0.44) | HRASESR1ESR2TOP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458069-B1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MERSANA THERAPEUTICS INC (US) | 2023-07-05 | — | — | EP | disclosed |