Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNB4 | O00305 | 3/20 | 0.37 |
| ▸ | CACNA1A | O00555 | 3/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.37 |
| ▸ | CACNG3 | O60359 | 3/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.37 |
| ▸ | CACNB3 | P54284 | 3/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.37 |
| ▸ | CACNG7 | P62955 | 3/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.37 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.37 |
| ▸ | CACNB1 | Q02641 | 3/20 | 0.37 |
| ▸ | CACNG1 | Q06432 | 3/20 | 0.37 |
| ▸ | CACNB2 | Q08289 | 3/20 | 0.37 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.37 |
| ▸ | CACNA1E | Q15878 | 3/20 | 0.37 |
| ▸ | CACNA2D4 | Q7Z3S7 | 3/20 | 0.37 |
| ▸ | CACNA2D3 | Q8IZS8 | 3/20 | 0.37 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3810960 | 0.74 | MCHR1 (0.43) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL2576544 | 0.73 | CACNB4 (0.48) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL2585915 | 0.72 | CACNB4 (0.51) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL3813155 | 0.71 | MCHR1 (0.43) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL12002756 | 0.64 | CACNB4 (0.40) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL2585800 | 0.64 | MCHR1 (0.42) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL2575845 | 0.62 | MCHR1 (0.46) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL3816551 | 0.62 | MCHR1 (0.46) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL12003013 | 0.60 | CACNB4 (0.40) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL793221 | 0.60 | TYK2 (0.44) | MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8049013-B2 | 5- [4-(azetidin-3-yloxy)-phenyl]-2-phenyl-5H-thiazolo[5,4-C] pyridin-4-one derivatives and their use as MCH receptor antagonists | ELI LILLY AND COMPANY (US) | 2011-11-01 | — | — | US | disclosed |
| US-20100069352-A1 | 5- [4-(AZETIDIN-3-YLOXY)-PHENYL]-2-PHENYL-5H-THIAZOLO[5,4-C] PYRIDIN-4-ONE DERIVATIVES AND THEIR USE AS MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069352-A1 | 5- [4-(AZETIDIN-3-YLOXY)-PHENYL]-2-PHENYL-5H-THIAZOLO[5,4-C] PYRIDIN-4-ONE DERIVATIVES AND THEIR USE AS MCH RECEPTOR ANTAGONISTS | MCHR1, MCHR2, HCRTR1 | CACNB4 3015/4885CACNA1A 2006/4885CACNA1G 1651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.