SCHEMBL25864333

SCHEMBL25864333

Cc1cccc2c(C3CCC(=O)NC3=O)nn(C(C)C(F)(F)F)c12

nearest known ligand 0.55

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
DDB1 Q16531 19/20 0.55
CRBN Q96SW2 19/20 0.55
POLB P06746 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25027088 0.81 DDB1 (0.77) DDB1CRBN
SCHEMBL24832984 0.74 DDB1 (0.72) DDB1CRBNPOLB
SCHEMBL23553084 0.73 DDB1 (0.73) DDB1CRBN
SCHEMBL24132057 0.72 DDB1 (0.72) DDB1CRBN
SCHEMBL30257102 0.71 DDB1 (0.75) DDB1CRBN
SCHEMBL30338206 0.71 DDB1 (1.00) DDB1CRBN
SCHEMBL31053795 0.71 DDB1 (0.75) DDB1CRBN
SCHEMBL25027185 0.71 DDB1 (1.00) DDB1CRBN
SCHEMBL25027164 0.71 DDB1 (0.75) DDB1CRBN
SCHEMBL30801214 0.71 DDB1 (0.66) DDB1CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023131167-A1 COMPOUND FOR INHIBITING AND DEGRADING IRAK4, AND PHARMACEUTICAL COMPOSITION AND PHARMACEUTICAL APPLICATION THEREOF 海思科医药集团股份有限公司 2023-07-13 WO disclosed