Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 20/20 | 0.83 |
| ▸ | TP53 | P04637 | 10/20 | 0.83 |
| ▸ | MDM4 | O15151 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL222058 | 1.00 | MDM2 (0.83) | MDM2TP53MDM4 | |
| SCHEMBL1957621 | 1.00 | MDM2 (0.83) | MDM2TP53MDM4 | |
| SCHEMBL2593580 | 1.00 | MDM2 (0.83) | MDM2TP53MDM4 | |
| SCHEMBL1956458 | 0.94 | MDM2 (0.74) | MDM2TP53MDM4 | |
| SCHEMBL222142 | 0.94 | MDM2 (0.74) | MDM2TP53MDM4 | |
| SCHEMBL222898 | 0.94 | MDM2 (0.89) | MDM2TP53MDM4 | |
| SCHEMBL1957264 | 0.93 | MDM2 (0.73) | MDM2TP53MDM4 | |
| SCHEMBL221301 | 0.93 | MDM2 (0.73) | MDM2TP53MDM4 | |
| SCHEMBL221903 | 0.93 | MDM2 (0.73) | MDM2TP53MDM4 | |
| SCHEMBL220129 | 0.92 | MDM2 (0.86) | MDM2TP53MDM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011134925-A1 | SPIROINDOLINONE PYRROLIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-11-03 | — | — | WO | disclosed |