Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.66 |
| ▸ | S1PR3 | Q99500 | 9/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2579544 | 0.84 | S1PR1 (0.77) | S1PR1S1PR3 | |
| SCHEMBL27921152 | 0.84 | S1PR1 (0.77) | S1PR1S1PR3 | |
| SCHEMBL2576403 | 0.83 | S1PR1 (0.82) | S1PR1 | |
| SCHEMBL12289131 | 0.81 | S1PR1 (0.81) | S1PR1 | |
| SCHEMBL12288618 | 0.80 | S1PR1 (0.77) | S1PR1S1PR3 | |
| SCHEMBL14696697 | 0.80 | S1PR1 (0.75) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL14696699 | 0.80 | S1PR1 (0.75) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL14696698 | 0.80 | S1PR1 (0.75) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL2577490 | 0.80 | S1PR1 (1.00) | S1PR1 | |
| SCHEMBL14696212 | 0.80 | S1PR1 (0.75) | S1PR1S1PR3S1PR4S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560969-A1 | 4 - (5 - ISOXAZOLYL OR 5 - PYRRAZOLYL -1,2,4- OXADIAZOL - 3 - YL) -MANDELIC ACID AMIDES AS SPHINGOSIN- 1 - PHOSPHATE 1 RRECEPTOR AGONISTS | Bristol-Myers Squibb Company (US) | 2013-02-27 | — | — | EP | disclosed |
| WO-2011133734-A1 | 4 - (5 - ISOXAZOLYL OR 5 - PYRRAZOLYL -1,2,4- OXADIAZOL - 3 - YL) -MANDELIC ACID AMIDES AS SPHINGOSIN- 1 - PHOSPHATE 1 RRECEPTOR AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-10-27 | — | — | WO | disclosed |