Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.64 |
| ▸ | EGFR | P00533 | 3/20 | 0.62 |
| ▸ | INSR | P06213 | 1/20 | 0.59 |
| ▸ | IGF1R | P08069 | 1/20 | 0.59 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.54 |
| ▸ | CCNK | O75909 | 1/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | CCND3 | P30281 | 1/20 | 0.53 |
| ▸ | CDK9 | P50750 | 1/20 | 0.53 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25872847 | 0.93 | ALK (0.63) | ALKEGFRINSRIGF1RZAP70 | |
| SCHEMBL25871925 | 0.93 | ALK (0.59) | ALKEGFRINSRIGF1RZAP70 | |
| SCHEMBL25869799 | 0.92 | ALK (0.75) | ALKEGFRINSRIGF1RZAP70 | |
| SCHEMBL30497526 | 0.91 | EGFR (0.67) | ALKEGFRINSRIGF1RZAP70 | |
| SCHEMBL25871972 | 0.91 | ALK (0.57) | ALKEGFRINSRIGF1RZAP70 | |
| SCHEMBL26495614 | 0.91 | EGFR (0.67) | ALKEGFRINSRIGF1RZAP70 | |
| SCHEMBL25869936 | 0.91 | EGFR (0.76) | ALKEGFRINSRIGF1RZAP70 | |
| SCHEMBL25872979 | 0.90 | ALK (0.57) | ALKEGFRINSRIGF1RZAP70 | |
| SCHEMBL25871927 | 0.89 | ALK (0.62) | ALKEGFRINSRIGF1R | |
| SCHEMBL25872052 | 0.88 | ALK (0.62) | ALKEGFRINSRIGF1RZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4212522-A1 | COMPOUNDS FOR SUPPRESSING EGFR MUTANT CANCER AND PHARMACEUTICAL USE THEREOF | J2H Biotech Inc. (KR) | 2023-07-19 | — | — | EP | disclosed |