Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30946649 | 0.88 | CYP2D6 (0.54) | CYP1A2CYP2D6CYP2C19KDM4EALDH1A1 | |
| SCHEMBL21199087 | 0.88 | CYP2D6 (0.54) | CYP1A2CYP2D6CYP2C19KDM4EALDH1A1 | |
| SCHEMBL25873500 | 0.85 | CYP2D6 (0.58) | CYP1A2CYP2D6CYP2C19KDM4EALDH1A1 | |
| SCHEMBL25873496 | 0.82 | KDM4E (0.59) | CYP1A2CYP2D6CYP2C19KDM4EALDH1A1 | |
| SCHEMBL17921471 | 0.81 | CYP1A2 (0.58) | CYP1A2CYP2D6CYP2C19KDM4EALDH1A1 | |
| SCHEMBL3280339 | 0.79 | CYP2D6 (0.56) | CYP1A2CYP2D6CYP2C19KDM4EALDH1A1 | |
| SCHEMBL14421398 | 0.79 | CYP2D6 (0.56) | CYP1A2CYP2D6CYP2C19KDM4EALDH1A1 | |
| SCHEMBL27958219 | 0.78 | CYP2D6 (0.66) | CYP1A2CYP2D6CYP2C19KDM4EALDH1A1 | |
| SCHEMBL30946652 | 0.77 | CYP1A2 (0.62) | CYP1A2CYP2D6CYP2C19KDM4EALDH1A1 | |
| SCHEMBL21198909 | 0.77 | CYP1A2 (0.62) | CYP1A2CYP2D6CYP2C19KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230374024-A1 | Compounds for the Treatment of Kinase-Dependent Disorders | EXELIXIS, INC. | 2023-11-23 | — | — | US | disclosed |
| US-11708367-B2 | Compounds for the treatment of kinase-dependent disorders | EXELIXIS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11708367-B2 | Compounds for the treatment of kinase-dependent disorders | ERBB2, ERBB3, MAP3K6 | CYP1A2 3994/4885CYP2D6 3930/4885CYP2C19 4454/4885 |
| US-20230374024-A1 | Compounds for the Treatment of Kinase-Dependent Disorders | ERBB2, ERBB3, MAP3K6 | CYP1A2 3994/4885CYP2D6 3930/4885CYP2C19 4454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.