Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | KIF5B | P33176 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 17/20 | 0.40 |
| ▸ | PAK4 | O96013 | 3/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 7/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25876231 | 0.94 | RET (0.45) | RETJAK2KIF5BKDRFLT3 | |
| SCHEMBL25876287 | 0.94 | RET (0.43) | RETJAK2KIF5BKDRFLT3 | |
| SCHEMBL25876038 | 0.93 | RET (0.43) | RETJAK2KIF5BKDRFLT3 | |
| SCHEMBL25875934 | 0.92 | RET (0.44) | RETJAK2KIF5BKDRFLT3 | |
| SCHEMBL25876318 | 0.91 | PLK4 (0.51) | RETJAK2KIF5BKDRFLT3 | |
| SCHEMBL25875971 | 0.91 | RET (0.47) | RETJAK2KIF5BKDRFLT3 | |
| SCHEMBL25876075 | 0.91 | RET (0.43) | RETJAK2KIF5BKDRFLT3 | |
| SCHEMBL25875746 | 0.90 | RET (0.46) | RETJAK2KIF5BKDRFLT3 | |
| SCHEMBL25876215 | 0.89 | PLK4 (0.52) | RETJAK2KIF5BKDRFLT3 | |
| SCHEMBL25876277 | 0.88 | RET (0.43) | RETJAK2KIF5BKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234954-A1 | COMPOUND USED AS RET KINASE INHIBITOR AND APPLICATION THEREOF | TYK MEDICINES, INC. (CN) | 2023-07-27 | — | — | US | disclosed |
| US-20230234954-A1 | COMPOUND USED AS RET KINASE INHIBITOR AND APPLICATION THEREOF | TYK MEDICINES, INC. (CN) | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234954-A1 | COMPOUND USED AS RET KINASE INHIBITOR AND APPLICATION THEREOF | RET, ROR1, FGFR3 | RET 1/4885JAK2 38/4885KIF5B 2655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.