Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11471749 | 0.86 | AKR1B1 (0.58) | CYP2A6CYP1A2AKR1B1ALDH1A1HPGD | |
| SCHEMBL16539783 | 0.83 | AKR1B1 (0.49) | CYP1A2AKR1B1ALDH1A1HPGDMAPT | |
| SCHEMBL25895988 | 0.82 | HPGD (0.49) | CYP2A6CYP1A2ALDH1A1HPGDMAPT | |
| SCHEMBL18789582 | 0.81 | CYP1A2 (0.50) | CYP2A6CYP1A2AKR1B1ALDH1A1HPGD | |
| SCHEMBL28145001 | 0.80 | NR4A1 (0.49) | CYP1A2AKR1B1ALDH1A1HPGDMAPT | |
| SCHEMBL28219428 | 0.79 | KDM4E (0.51) | CYP1A2AKR1B1ALDH1A1HPGDMAPT | |
| SCHEMBL5898012 | 0.78 | CYP1A2 (0.55) | CYP2A6CYP1A2AKR1B1ALDH1A1HPGD | |
| SCHEMBL5898006 | 0.78 | CYP1A2 (0.55) | CYP2A6CYP1A2AKR1B1ALDH1A1HPGD | |
| SCHEMBL6367430 | 0.76 | CYP1A2 (0.57) | CYP2A6CYP1A2ALDH1A1HPGDKDM4E | |
| SCHEMBL7260877 | 0.75 | CYP1A2 (0.57) | CYP2A6CYP1A2AKR1B1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234965-A1 | N-LINKED MACROCYCLIC 4-(PYRAZOL-5-YL)-INDOLE DERIVATIVES AS INHIBITORS OF MCL-1 | JANSSEN PHARMACEUTICA NV (BE) | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234965-A1 | N-LINKED MACROCYCLIC 4-(PYRAZOL-5-YL)-INDOLE DERIVATIVES AS INHIBITORS OF MCL-1 | MCL1, BCL2L1, BAK1 | CYP2A6 4614/4885CYP1A2 4035/4885AKR1B1 3165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.