Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 7/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | TYMP | P19971 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8851565 | 0.81 | CYP1A2 (0.55) | CYP1A2CYP2A6ALDH1A1APOBEC3AAPOBEC3G | |
| SCHEMBL5898006 | 0.81 | CYP1A2 (0.55) | CYP1A2CYP2A6ALDH1A1APOBEC3AAPOBEC3G | |
| SCHEMBL11738780 | 0.80 | CYP1A2 (0.53) | CYP1A2CYP2A6ALDH1A1HPGDHSD17B10 | |
| SCHEMBL7411772 | 0.79 | CYP1A2 (0.42) | CYP1A2CYP2A6ALDH1A1HPGDKDM4E | |
| SCHEMBL6367430 | 0.79 | CYP1A2 (0.57) | CYP1A2CYP2A6ALDH1A1APOBEC3AAPOBEC3G | |
| SCHEMBL7260877 | 0.78 | CYP1A2 (0.57) | CYP1A2CYP2A6ALDH1A1APOBEC3AAPOBEC3G | |
| SCHEMBL8852070 | 0.78 | CYP1A2 (0.57) | CYP1A2CYP2A6ALDH1A1APOBEC3AAPOBEC3G | |
| SCHEMBL11741652 | 0.77 | NQO1 (0.43) | ALDH1A1ERN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL23465385 | 0.77 | CYP1A2 (0.55) | CYP1A2CYP2A6ALDH1A1APOBEC3AAPOBEC3G | |
| SCHEMBL15345412 | 0.77 | CYP1A2 (0.55) | CYP1A2CYP2A6ALDH1A1APOBEC3AAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234965-A1 | N-LINKED MACROCYCLIC 4-(PYRAZOL-5-YL)-INDOLE DERIVATIVES AS INHIBITORS OF MCL-1 | JANSSEN PHARMACEUTICA NV (BE) | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234965-A1 | N-LINKED MACROCYCLIC 4-(PYRAZOL-5-YL)-INDOLE DERIVATIVES AS INHIBITORS OF MCL-1 | MCL1, BCL2L1, BAK1 | CYP1A2 4035/4885CYP2A6 4614/4885ALDH1A1 1295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.