SCHEMBL25883295

SCHEMBL25883295

COc1ccccc1N(C)I

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.52
CA2 P00918 3/20 0.52
CA7 P43166 2/20 0.52
CA9 Q16790 2/20 0.52
CA12 O43570 1/20 0.52
CA4 P22748 1/20 0.52
CA14 Q9ULX7 1/20 0.52
ALDH1A1 P00352 2/20 0.43
TP53 P04637 1/20 0.43
TSHR P16473 1/20 0.43
ADRA2B P18089 1/20 0.43
PTGS1 P23219 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
SLC6A2 P23975 1/20 0.43
SLC6A4 P31645 1/20 0.43
MAPK1 P28482 1/20 0.41
HTT P42858 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
AOC3 Q16853 1/20 0.40
ENPP2 Q13822 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25883275 0.82 CA12 (0.35) CA1CA2CA7CA9CA12
SCHEMBL2539698 0.81 CA1 (0.57) CA1CA2CA7CA9CA12
SCHEMBL17485907 0.81 CA1 (0.57) CA1CA2CA7CA9CA12
Hydrochloric Acid SCHEMBL2862732 0.79 CA1 (0.55) CA1CA2CA7CA9CA12
SCHEMBL4540956 0.78 CA1 (0.60) CA1CA2CA7CA9CA12
SCHEMBL15541407 0.77 CA1 (0.52) CA1CA2CA7CA9CA12
SCHEMBL18224917 0.77 CA1 (0.52) CA1CA2CA7CA9CA12
SCHEMBL31461202 0.77 CA1 (0.52) CA1CA2CA7CA9CA12
SCHEMBL18884315 0.77 CA1 (0.52) CA1CA2CA7CA9CA12
Nitrogen SCHEMBL10985025 0.77 CA1 (0.52) CA1CA2CA7CA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023141511-A1 POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 VANDERBILT UNIVERSITY (US) 2023-07-27 WO disclosed