Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 8/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.38 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.38 |
| ▸ | ADH1B | P00325 | 1/20 | 0.36 |
| ▸ | ADH1C | P00326 | 1/20 | 0.36 |
| ▸ | ADH1A | P07327 | 1/20 | 0.36 |
| ▸ | ADH4 | P08319 | 1/20 | 0.36 |
| ▸ | ADH7 | P40394 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19057654 | 0.88 | EPHX1 (0.50) | EPHX1MMP8ZDHHC20ZDHHC2 | |
| SCHEMBL25881306 | 0.88 | EPHX1 (0.50) | EPHX1MMP8ZDHHC20ZDHHC2 | |
| SCHEMBL22861925 | 0.88 | EPHX1 (0.50) | EPHX1MMP8ZDHHC20ZDHHC2 | |
| SCHEMBL25697792 | 0.88 | EPHX1 (0.50) | EPHX1MMP8ZDHHC20ZDHHC2 | |
| SCHEMBL20322090 | 0.86 | EPHX1 (0.47) | ALDH1A1TSHREPHX1MMP8ZDHHC20 | |
| SCHEMBL19200596 | 0.80 | EPHX1 (0.41) | TSHREPHX1ZDHHC20ZDHHC2 | |
| SCHEMBL9290204 | 0.75 | — | — | |
| SCHEMBL25435977 | 0.74 | TSHR (0.87) | ALDH1A1TSHRS1PR2S1PR4S1PR1 | |
| SCHEMBL868091 | 0.74 | TSHR (0.87) | ALDH1A1TSHRS1PR2S1PR4S1PR1 | |
| SCHEMBL11519282 | 0.74 | TSHR (0.87) | ALDH1A1TSHRS1PR2S1PR4S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11707457-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11707457-B2 | IRAK degraders and uses thereof | IRAK2, IRAK3, IRAK1 | ALDH1A1 2776/4885TSHR 3319/4885S1PR2 2608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.