Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 17/20 | 0.58 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 4/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 4/20 | 0.40 |
| ▸ | ELOC | Q15369 | 1/20 | 0.38 |
| ▸ | ELOB | Q15370 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25898389 | 0.90 | VHL (0.62) | VHLSOS1SMARCA2SMARCA4ELOC | |
| SCHEMBL25898319 | 0.90 | VHL (0.73) | VHLHDAC3HDAC1HDAC2ELOC | |
| SCHEMBL25898292 | 0.90 | VHL (0.73) | VHLHDAC3HDAC1HDAC2ELOC | |
| SCHEMBL30960090 | 0.90 | VHL (0.73) | VHLHDAC3HDAC1HDAC2ELOC | |
| SCHEMBL30959991 | 0.90 | VHL (0.73) | VHLHDAC3HDAC1HDAC2ELOC | |
| SCHEMBL25898309 | 0.89 | VHL (0.46) | VHLSOS1HDAC3HDAC1HDAC2 | |
| SCHEMBL25898354 | 0.87 | VHL (0.53) | VHLSOS1HDAC3HDAC1HDAC2 | |
| SCHEMBL25898331 | 0.85 | VHL (0.63) | VHLSOS1SMARCA2SMARCA4ELOC | |
| SCHEMBL25771807 | 0.84 | VHL (0.76) | VHLSOS1SMARCA2SMARCA4ELOC | |
| SCHEMBL25900363 | 0.84 | VHL (0.54) | VHLSOS1SMARCA2SMARCA4ELOC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141570-A2 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF KRAS | ARVINAS OPERATIONS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |