Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 6/20 | 0.49 |
| ▸ | TDO2 | P48775 | 6/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CPN1 | P15169 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | GNRHR | P30968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31067420 | 0.77 | IDO1 (0.42) | IDO1TDO2CYP3A4ALDH1A1GAA | |
| SCHEMBL17064312 | 0.77 | IDO1 (0.42) | IDO1TDO2CYP3A4ALDH1A1GAA | |
| SCHEMBL29406997 | 0.70 | CYP3A4 (0.48) | CYP3A4ALDH1A1TP53CASP1RECQL | |
| SCHEMBL1098188 | 0.70 | CYP3A4 (0.48) | CYP3A4ALDH1A1TP53CASP1RECQL | |
| SCHEMBL11093862 | 0.69 | IDO1 (0.46) | IDO1TDO2CYP3A4GAACASP1 | |
| SCHEMBL9157662 | 0.69 | CYP3A4 (0.47) | CYP3A4ALDH1A1TP53AOC3CASP1 | |
| SCHEMBL20852303 | 0.69 | CYP3A4 (0.47) | CYP3A4ALDH1A1TP53AOC3CASP1 | |
| SCHEMBL28582936 | 0.69 | CYP3A4 (0.47) | CYP3A4ALDH1A1TP53AOC3CASP1 | |
| SCHEMBL11778315 | 0.68 | IDO1 (0.53) | IDO1TDO2CYP3A4ALDH1A1AOC3 | |
| SCHEMBL17064557 | 0.68 | IDO1 (0.46) | IDO1TDO2CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11708333-B2 | Human plasma kallikrein inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11708333-B2 | Human plasma kallikrein inhibitors | KLKB1, KLK1, KLK5 | IDO1 2690/4885TDO2 4283/4885CYP3A4 1603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.