Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | CASP7 | P55210 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25316946 | 1.00 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2HTTMEN1 | |
| SCHEMBL25901214 | 1.00 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2HTTMEN1 | |
| SCHEMBL25316427 | 1.00 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2HTTMEN1 | |
| SCHEMBL25319179 | 1.00 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2HTTMEN1 | |
| SCHEMBL25901215 | 1.00 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2HTTMEN1 | |
| SCHEMBL25318728 | 1.00 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2HTTMEN1 | |
| SCHEMBL31140806 | 0.93 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2HTTMEN1 | |
| SCHEMBL25901195 | 0.93 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2HTTMEN1 | |
| SCHEMBL25318693 | 0.93 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2HTTMEN1 | |
| SCHEMBL16400464 | 0.89 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139534-A1 | SPIROCYCLIC PIPERIDINYL DERIVATIVES AS COMPLEMENT FACTOR B INHIBITORS AND USES THEREOF | NOVARTIS AG (CH) | 2023-07-27 | — | — | WO | disclosed |