Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3461672 | 0.87 | HPGD (0.50) | HPGDUSP2SMN1; SMN2EPHX1ALDH1A1 | |
| SCHEMBL22595464 | 0.83 | HPGD (0.52) | HPGDUSP2SMN1; SMN2EPHX1ALDH1A1 | |
| SCHEMBL337749 | 0.81 | USP30 (0.43) | NR1H2HPGDUSP2SMN1; SMN2EPHX1 | |
| SCHEMBL15770180 | 0.81 | USP30 (0.43) | NR1H2HPGDUSP2SMN1; SMN2EPHX1 | |
| SCHEMBL2674513 | 0.76 | NR1H2 (0.44) | NR1H2HPGDUSP2SMN1; SMN2EPHX1 | |
| SCHEMBL24359058 | 0.74 | NR1H2 (0.49) | NR1H2HPGDUSP2SMN1; SMN2EPHX1 | |
| SCHEMBL15664395 | 0.74 | HPGD (0.51) | NR1H2HPGDUSP2SMN1; SMN2EPHX1 | |
| SCHEMBL20743068 | 0.73 | HPGD (0.54) | NR1H2HPGDUSP2SMN1; SMN2EPHX1 | |
| SCHEMBL4629128 | 0.73 | USP2 (0.41) | HPGDUSP2SMN1; SMN2EPHX1MEN1 | |
| SCHEMBL3461675 | 0.72 | HPGD (0.50) | HPGDUSP2SMN1; SMN2EPHX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023134266-A1 | 2-PIPERIDYL OR 2-PYRAZOLYL SUBSTITUTED PYRIMIDINE COMPOUND SERVING AS EGFR INHIBITOR | 苏州浦合医药科技有限公司 | 2023-07-20 | — | — | WO | disclosed |