Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26022086 | 0.88 | TDP1 (0.44) | MAPK1EPHX2TDP1MMP3S1PR1 | |
| SCHEMBL25318341 | 0.85 | ALOX5AP (0.45) | SMN1; SMN2GAAKMT2ATSHRMEN1 | |
| SCHEMBL26024304 | 0.85 | TSHR (0.47) | GAAKMT2ATSHRMEN1MAPT | |
| SCHEMBL25902474 | 0.85 | TDP1 (0.49) | MAPK1EPHX2TDP1MMP3S1PR1 | |
| SCHEMBL25316389 | 0.83 | CYP2D6 (0.35) | KMT2ATSHRMEN1MAPTALDH1A1 | |
| SCHEMBL25902138 | 0.83 | TDP1 (0.46) | MAPK1EPHX2TDP1MMP3S1PR1 | |
| SCHEMBL26022091 | 0.82 | TDP1 (0.45) | MAPK1EPHX2TDP1MMP3S1PR1 | |
| SCHEMBL25902002 | 0.82 | EPHX2 (0.46) | MAPK1EPHX2TDP1MMP3S1PR1 | |
| SCHEMBL25902004 | 0.80 | TSHR (0.47) | MAPK1EPHX2TDP1MMP3S1PR1 | |
| SCHEMBL26022094 | 0.79 | TDP1 (0.42) | MAPK1EPHX2TDP1MMP3S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |