Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15742035 | 0.91 | EGFR (0.38) | EGFRIRAK4 | |
| SCHEMBL30911451 | 0.83 | EGFR (0.47) | EGFRIRAK4JAK2 | |
| SCHEMBL30616553 | 0.80 | PIK3CD (0.42) | EGFRIRAK4PIK3CD | |
| SCHEMBL15741966 | 0.77 | EGFR (0.52) | EGFR | |
| SCHEMBL16339442 | 0.76 | EGFR (0.40) | EGFR | |
| SCHEMBL23753887 | 0.72 | MTOR (0.43) | IRAK4PIK3CD | |
| SCHEMBL19015251 | 0.71 | IRAK4 (0.38) | IRAK4JAK2 | |
| SCHEMBL30042590 | 0.68 | JAK2 (0.47) | IRAK4PIK3CDJAK2JAK1 | |
| SCHEMBL30911637 | 0.66 | PIK3CA (0.39) | EGFRIRAK4PIK3CD | |
| SCHEMBL27263226 | 0.65 | PIK3CD (0.46) | IRAK4PIK3CDJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023134266-A1 | 2-PIPERIDYL OR 2-PYRAZOLYL SUBSTITUTED PYRIMIDINE COMPOUND SERVING AS EGFR INHIBITOR | 苏州浦合医药科技有限公司 | 2023-07-20 | — | — | WO | disclosed |