Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | RORC | P51449 | 10/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29631546 | 0.79 | IDO1 (0.60) | GRM5BRAFCNR1NPC1RAB9A | |
| SCHEMBL20898564 | 0.79 | IDO1 (0.60) | GRM5BRAFCNR1NPC1RAB9A | |
| SCHEMBL29631509 | 0.69 | IDO1 (0.75) | GRM5BRAFMEN1KMT2ANPC1 | |
| SCHEMBL20899512 | 0.69 | IDO1 (0.75) | GRM5BRAFMEN1KMT2ANPC1 | |
| SCHEMBL20898568 | 0.65 | IDO1 (0.80) | BRAFNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL19087022 | 0.64 | GRM5 (0.67) | GRM5BRAFMEN1KMT2A | |
| SCHEMBL6541906 | 0.64 | RXFP1 (0.56) | GRM5MEN1KMT2ANPC1RAB9A | |
| SCHEMBL9588685 | 0.64 | GRM5 (0.69) | GRM5BRAF | |
| SCHEMBL30798963 | 0.64 | F2 (0.55) | GRM5BRAFMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27383419 | 0.64 | NPC1 (0.63) | GRM5BRAFCNR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3694506-B1 | NOVEL SUBSTITUTED PHENYLOXETANE AND PHENYLTETRAHYDROFURAN COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-08-02 | — | — | EP | disclosed |