Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 7/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.45 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.45 |
| ▸ | AHR | P35869 | 2/20 | 0.45 |
| ▸ | NR1I3 | Q14994 | 2/20 | 0.45 |
| ▸ | VDR | P11473 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12179678 | 0.84 | MAPK1 (0.51) | CYP1A2CYP3A4CYP2C9CYP2B6AHR | |
| SCHEMBL12179653 | 0.82 | PDGFRB (0.52) | CYP1A2CYP3A4CYP2C9CYP2B6AHR | |
| SCHEMBL12179647 | 0.82 | CYP1A2 (0.51) | CYP1A2CYP3A4CYP2C9CYP2B6AHR | |
| SCHEMBL14891297 | 0.81 | CYP1A2 (0.53) | CYP1A2CYP3A4CYP2C9CYP2B6AHR | |
| SCHEMBL2590879 | 0.80 | CYP1A2 (0.48) | CYP1A2CYP3A4CYP2C9CYP2B6AHR | |
| SCHEMBL14904343 | 0.80 | CYP1A2 (0.49) | CYP1A2CYP3A4CYP2C9CYP2B6AHR | |
| SCHEMBL14904350 | 0.80 | CYP1A2 (0.53) | CYP1A2CYP3A4CYP2C9CYP2B6AHR | |
| SCHEMBL2586616 | 0.79 | CYP1A2 (0.51) | CYP1A2CYP3A4CYP2C9CYP2B6AHR | |
| SCHEMBL12179457 | 0.79 | CYP1A2 (0.52) | CYP1A2CYP3A4CYP2C9CYP2B6AHR | |
| SCHEMBL12179649 | 0.78 | ADORA2A (0.48) | CYP1A2CYP3A4CYP2C9CYP2B6AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130109693-A1 | DERIVATIVES OF PYRIDO [3,2-D] PYRIMIDINE, METHODS FOR PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | UNIVERSITE D'ORLEANS (FR) | 2013-05-02 | — | — | US | disclosed |
| WO-2011135259-A1 | PYRIDO[3,2-D]PYRIMIDINE DERIVATIVES, PROCESSES FOR PREPARING SAME AND THERAPEUTIC USES THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) (FR) | 2011-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109693-A1 | DERIVATIVES OF PYRIDO [3,2-D] PYRIMIDINE, METHODS FOR PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | DPYD, CYP2D6, TYMS | CYP1A2 36/4885CYP3A4 45/4885CYP2C9 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.