Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 19/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594388 | 0.90 | GRM4 (0.64) | GRM4NPC1ALDH1A1LMNAAGTR1 | |
| SCHEMBL2590990 | 0.79 | GRM4 (0.65) | GRM4NPC1ALDH1A1LMNAAGTR1 | |
| SCHEMBL2594330 | 0.78 | GRM4 (0.66) | GRM4NPC1ALDH1A1LMNAAGTR1 | |
| SCHEMBL12182122 | 0.78 | GRM4 (1.00) | GRM4 | |
| SCHEMBL2593900 | 0.77 | GRM4 (0.64) | GRM4NPC1RAB9A | |
| SCHEMBL2591083 | 0.73 | GRM4 (0.59) | GRM4NPC1ALDH1A1LMNAAGTR1 | |
| SCHEMBL2591117 | 0.73 | GRM4 (0.66) | GRM4NPC1ALDH1A1LMNATP53 | |
| SCHEMBL2594386 | 0.73 | GRM4 (0.66) | GRM4NPC1ALDH1A1LMNAAGTR1 | |
| SCHEMBL2593618 | 0.72 | GRM4 (0.66) | GRM4NPC1ALDH1A1LMNATP53 | |
| SCHEMBL12182139 | 0.71 | GRM4 (1.00) | GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2568809-A1 | HETEROCYCLIC SULFONE MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION | Vanderbilt University (US) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011143466-A1 | HETEROCYCLIC SULFONE MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION | VANDERBILT UNIVERSITY (US) | 2011-11-17 | — | — | WO | disclosed |