SCHEMBL25912600

SCHEMBL25912600

CCCC(=O)Nc1ncnn2c([C@]3(C)O[C@H](CO)[C@@H](OC(=O)C(C)C)[C@H]3O)ccc12

nearest known ligand 0.39

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ TMPRSS2 O15393 1/20 0.39
▸ TSHR P16473 1/20 0.32
▸ SLC5A1 P13866 1/20 0.31
▸ SLC5A2 P31639 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25912383 0.92 TMPRSS2 (0.39) TMPRSS2TSHRSLC5A1SLC5A2
SCHEMBL25912420 0.91 TMPRSS2 (0.40) TMPRSS2TSHR
SCHEMBL25912633 0.91 TMPRSS2 (0.38) TMPRSS2TSHRSLC5A1SLC5A2
SCHEMBL25912570 0.90 TMPRSS2 (0.40) TMPRSS2TSHR
SCHEMBL24789764 0.88 TMPRSS2 (0.52) TMPRSS2TSHR
SCHEMBL25912578 0.88 TMPRSS2 (0.37) TMPRSS2
SCHEMBL25912596 0.86 TMPRSS2 (0.40) TMPRSS2
SCHEMBL25912595 0.86 TMPRSS2 (0.47) TMPRSS2
SCHEMBL24917211 0.86 TMPRSS2 (0.39) TMPRSS2
SCHEMBL25912502 0.86 TMPRSS2 (0.37) TMPRSS2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230233593-A1 ORALLY-BIOAVAILABLE NUCLEOSIDE ANALOGS VenatoRx Pharmaceuticals, Inc. 2023-07-27 — — US disclosed
US-11638715-B2 Orally-bioavailable nucleoside analogs VenatoRx Pharmaceuticals, Inc. (US) 2023-05-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11638715-B2 Orally-bioavailable nucleoside analogs SLC29A2, SLC29A1, PNP TMPRSS2 100/4885TSHR 4711/4885SLC5A1 171/4885
US-20230233593-A1 ORALLY-BIOAVAILABLE NUCLEOSIDE ANALOGS SLC29A2, SLC29A1, PNP TMPRSS2 100/4885TSHR 4711/4885SLC5A1 171/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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