Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22048340 | 0.84 | DAO (0.40) | IDO1TDO2ACHEKMT2AMEN1 | |
| SCHEMBL29173228 | 0.83 | KMT2A (0.38) | VKORC1TYRKMT2AMEN1TAAR1 | |
| SCHEMBL21910183 | 0.78 | TAAR1 (0.36) | IDO1TDO2ACHEKMT2AMEN1 | |
| SCHEMBL30411144 | 0.77 | IDO1 (0.50) | TYRIDO1TDO2ACHEKMT2A | |
| SCHEMBL16154382 | 0.77 | IDO1 (0.50) | TYRIDO1TDO2ACHEKMT2A | |
| SCHEMBL17071857 | 0.77 | IDO1 (0.50) | TYRIDO1TDO2ACHEKMT2A | |
| SCHEMBL17071859 | 0.77 | IDO1 (0.50) | TYRIDO1TDO2ACHEKMT2A | |
| SCHEMBL3088422 | 0.74 | TSHR (0.41) | VKORC1TYRACHEKMT2ATAAR1 | |
| SCHEMBL7499823 | 0.74 | TAAR1 (0.50) | TYRKMT2ATAAR1ADRA2AADRA2C | |
| SCHEMBL169730 | 0.74 | TAAR1 (0.50) | TYRKMT2ATAAR1ADRA2AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814348-B9 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-11-01 | — | — | EP | disclosed |
| EP-3814348-B1 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-08-02 | — | — | EP | disclosed |