Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4928772 | 0.72 | KDM4E (0.44) | KDM4EALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL10730858 | 0.65 | — | — | |
| SCHEMBL31368735 | 0.64 | HCAR2 (0.38) | — | |
| SCHEMBL31507341 | 0.62 | — | — | |
| SCHEMBL31368732 | 0.61 | DYRK1B (0.34) | ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL21721288 | 0.60 | — | — | |
| SCHEMBL21721241 | 0.59 | HPGD (0.33) | SMN1; SMN2 | |
| SCHEMBL21719497 | 0.59 | — | — | |
| SCHEMBL3782929 | 0.58 | SRC (0.58) | KDM4EALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL21719500 | 0.58 | HPGD (0.33) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566866-A1 | 4 SUBSTITUTED PYRAZOLOPYRIMIDINES USEFUL AS PKC-THETA INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011139273-A1 | 4 SUBSTITUTED PYRAZOLOPYRIMIDINES USEFUL AS PKC-THETA INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-11-10 | — | — | WO | disclosed |