SCHEMBL25928951

SCHEMBL25928951

Cc1ccc(S(=O)(=O)OCCC(F)(F)CCOc2ccc(C3CCN(c4ccc(C#N)c(C(F)(F)F)c4)CC3)cc2)cc1

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 10/20 0.40
SCN9A Q15858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31476797 0.93 AR (0.42) AR
SCHEMBL25329148 0.90 AR (0.44) ARSCN9A
SCHEMBL25328182 0.84 AR (0.42) AR
SCHEMBL31131388 0.83 AR (0.40) ARSCN9A
SCHEMBL25328831 0.78 AR (0.44) AR
SCHEMBL25329434 0.78 AR (0.42) AR
SCHEMBL25329956 0.78 AR (0.42) ARSCN9A
SCHEMBL25936331 0.78 AR (0.44) ARSCN9A
SCHEMBL25936546 0.78 AR (0.44) ARSCN9A
SCHEMBL31131387 0.77 AR (0.42) AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118574821-A Compounds and their use in the treatment of cancer 阿斯利康(瑞典)有限公司 2024-08-30 CN disclosed
WO-2023139199-A1 COMPOUNDS AND THEIR USE IN TREATING CANCER ASTRAZENECA AB (SE) 2023-07-27 WO disclosed