Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 18/20 | 0.76 |
| ▸ | EZH1 | Q92800 | 4/20 | 0.76 |
| ▸ | EED | O75530 | 9/20 | 0.58 |
| ▸ | SUZ12 | Q15022 | 9/20 | 0.58 |
| ▸ | RBBP4 | Q09028 | 3/20 | 0.57 |
| ▸ | RBBP7 | Q16576 | 2/20 | 0.57 |
| ▸ | AEBP2 | Q6ZN18 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12180194 | 0.92 | EZH2 (0.65) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL2595214 | 0.88 | EZH2 (0.60) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL2592051 | 0.87 | EZH2 (0.65) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL2595868 | 0.86 | EZH2 (1.00) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL29351554 | 0.86 | EZH2 (1.00) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL12180118 | 0.86 | EZH2 (0.63) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL12180091 | 0.85 | EZH2 (0.85) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL2592708 | 0.84 | EZH2 (0.61) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL16360903 | 0.84 | EZH2 (0.61) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL12180205 | 0.84 | EZH2 (0.94) | EZH2EZH1EEDSUZ12RBBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011140324-A1 | INDOLES | GLAXOSMITHKLINE LLC (US) | 2011-11-10 | — | — | WO | disclosed |