Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.41 |
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | RAB9A | P51151 | 8/20 | 0.41 |
| ▸ | NPC1 | O15118 | 7/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 8/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.33 |
| ▸ | RECQL | P46063 | 6/20 | 0.33 |
| ▸ | NR4A1 | P22736 | 4/20 | 0.33 |
| ▸ | APEX1 | P27695 | 3/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2581371 | 0.77 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPTRAB9ANPC1TP53 | |
| SCHEMBL2581375 | 0.77 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPTRAB9ANPC1TP53 | |
| SCHEMBL17755741 | 0.76 | GAA (0.43) | SMN1; SMN2MAPTRAB9ANPC1TP53 | |
| SCHEMBL2595492 | 0.76 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPTRAB9AALDH1A1CYP2C9 | |
| SCHEMBL2583719 | 0.75 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPTRAB9ANPC1TP53 | |
| SCHEMBL2590304 | 0.75 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPTRAB9ANPC1TP53 | |
| SCHEMBL2583717 | 0.75 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPTRAB9ANPC1TP53 | |
| SCHEMBL2596227 | 0.74 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPTRAB9ANPC1TP53 | |
| SCHEMBL2596210 | 0.74 | SMN1; SMN2 (0.35) | SMN1; SMN2ALDH1A1CYP2C9ALOX5AP | |
| SCHEMBL2596228 | 0.74 | SMN1; SMN2 (0.35) | SMN1; SMN2ALDH1A1KMT2ACYP2C9ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569319-A1 | HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011141396-A1 | HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-11-17 | — | — | WO | disclosed |