Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.74 |
| ▸ | MAPT | P10636 | 5/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.74 |
| ▸ | CLK1 | P49759 | 4/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.74 |
| ▸ | MEN1 | O00255 | 4/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.74 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.74 |
| ▸ | CLK3 | P49761 | 3/20 | 0.74 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.74 |
| ▸ | HPGD | P15428 | 3/20 | 0.74 |
| ▸ | HTT | P42858 | 3/20 | 0.74 |
| ▸ | PIM1 | P11309 | 2/20 | 0.74 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.74 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.74 |
| ▸ | MAP3K19 | Q56UN5 | 2/20 | 0.74 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.74 |
| ▸ | CSNK1G3 | Q9Y6M4 | 2/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.74 |
| ▸ | CLK2 | P49760 | 2/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2977826 | 0.85 | DYRK1A (1.00) | DYRK1AMAPTHSD17B10CLK1ALDH1A1 | |
| SCHEMBL2977830 | 0.85 | DYRK1A (1.00) | DYRK1AMAPTHSD17B10CLK1ALDH1A1 | |
| SCHEMBL24718937 | 0.84 | MAPT (1.00) | DYRK1AMAPTHSD17B10CLK1ALDH1A1 | |
| SCHEMBL4157023 | 0.82 | DYRK1A (0.76) | DYRK1AMAPTHSD17B10CLK1ALDH1A1 | |
| SCHEMBL4157020 | 0.82 | DYRK1A (0.76) | DYRK1AMAPTHSD17B10CLK1ALDH1A1 | |
| SCHEMBL8031777 | 0.82 | DYRK1A (0.76) | DYRK1AMAPTHSD17B10CLK1ALDH1A1 | |
| SCHEMBL8036087 | 0.81 | DYRK1A (0.74) | DYRK1AMAPTHSD17B10CLK1ALDH1A1 | |
| SCHEMBL24718939 | 0.81 | DYRK1A (0.74) | DYRK1AMAPTHSD17B10CLK1ALDH1A1 | |
| SCHEMBL8036803 | 0.79 | DYRK1A (0.74) | DYRK1AMAPTHSD17B10CLK1ALDH1A1 | |
| SCHEMBL24534821 | 0.79 | DYRK1A (0.70) | DYRK1AMAPTHSD17B10CLK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3840749-B1 | COMPOUNDS FOR TREATING CARDIAC VALVE DISEASE | THE J DAVID GLADSTONE INST A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J DAVID GLADSTONE (US) | 2023-08-09 | — | — | EP | disclosed |