SCHEMBL25935855

SCHEMBL25935855

COC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)CCc1ccc(-c2ccc(CCCCNC(=N)NC(=O)c3nc(Cl)c(N)nc3N)cc2)cc1)C(C)C

nearest known ligand 0.40

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SCNN1A P37088 20/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30605325 1.00 SCNN1A (0.40) SCNN1A
SCHEMBL30605341 0.94 SCNN1A (0.43) SCNN1A
SCHEMBL25935181 0.94 SCNN1A (0.43) SCNN1A
SCHEMBL25935305 0.94 SCNN1A (0.43) SCNN1A
SCHEMBL25335038 0.93 SCNN1A (0.38) SCNN1A
SCHEMBL25946828 0.93 SCNN1A (0.38) SCNN1A
SCHEMBL25946000 0.91 SCNN1A (0.40) SCNN1A
SCHEMBL25944724 0.90 SCNN1A (0.45) SCNN1A
SCHEMBL25335942 0.86 SCNN1A (0.42) SCNN1A
SCHEMBL25336494 0.86 SCNN1A (0.44) SCNN1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023146892-A1 BIPHENYL-SUBSTITUTED EPITHELIAL SODIUM CHANNEL BLOCKING COMPOUNDS PARION SCIENCES, INC. (US) 2023-08-03 WO disclosed