Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 15/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25938538 | 0.86 | MAP4K1 (0.58) | MAP4K1ALDH1A1TSHRHSD17B10KDM4E | |
| SCHEMBL25942610 | 0.84 | MAP4K1 (0.50) | MAP4K1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL25941003 | 0.82 | MAP4K1 (0.42) | MAP4K1ALDH1A1KDM4EPTGER3 | |
| SCHEMBL25943166 | 0.82 | MAP4K1 (0.47) | MAP4K1ALDH1A1TSHRHSD17B10KDM4E | |
| SCHEMBL25939365 | 0.82 | MAP4K1 (0.54) | MAP4K1ALDH1A1TSHRHSD17B10KDM4E | |
| SCHEMBL25945823 | 0.81 | MAP4K1 (0.40) | MAP4K1ALDH1A1TSHRHSD17B10KDM4E | |
| SCHEMBL25942729 | 0.81 | MAP4K1 (0.50) | MAP4K1ALDH1A1TSHRHSD17B10KDM4E | |
| SCHEMBL25940536 | 0.78 | MAP4K1 (0.49) | MAP4K1ALDH1A1TSHRHSD17B10KDM4E | |
| SCHEMBL25938321 | 0.77 | MAP4K1 (0.60) | MAP4K1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL21683545 | 0.76 | MAP4K1 (0.59) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219460-A1 | TRANSGLUTAMINASE 2 (TG2) INHIBITORS | Sitari Pharma, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |