Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 7/20 | 0.48 |
| ▸ | BRAF | P15056 | 5/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 4/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.46 |
| ▸ | YES1 | P07947 | 2/20 | 0.46 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.46 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | ABL2 | P42684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL229860 | 0.84 | BRAF (0.68) | SRCBRAFRIPK2PDGFRBYES1 | |
| SCHEMBL226245 | 0.83 | SRC (0.67) | SRCBRAFRIPK2PDGFRBYES1 | |
| SCHEMBL2580765 | 0.75 | SRC (0.46) | SRCBRAFRIPK2PDGFRBYES1 | |
| SCHEMBL42236 | 0.74 | SRC (0.57) | SRCBRAFPDGFRBABL1LCK | |
| SCHEMBL41314 | 0.73 | BRAF (0.42) | SRCBRAFPDGFRBABL1FGFR1 | |
| SCHEMBL41349 | 0.72 | SRC (0.62) | SRCBRAFPDGFRBFGFR1 | |
| SCHEMBL229386 | 0.72 | BRAF (0.43) | SRCBRAFRIPK2PDGFRBYES1 | |
| SCHEMBL229387 | 0.72 | BRAF (0.43) | SRCBRAFRIPK2PDGFRBYES1 | |
| SCHEMBL40934 | 0.72 | SYK (0.47) | SRCBRAFABL1KDR | |
| SCHEMBL2576460 | 0.71 | BRAF (0.41) | SRCBRAFRIPK2PDGFRBYES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2381943-A1 | SUBSTITUTED QUINAZOLINE COMPOUNDS | Fovea Pharmaceuticals (FR) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010076238-A1 | SUBSTITUTED QUINAZOLINE COMPOUNDS | FOVEA PHARMACEUTICALS SA (FR) | 2010-07-08 | — | — | WO | disclosed |