Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 5/20 | 0.44 |
| ▸ | CCND1 | P24385 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.42 |
| ▸ | CCND3 | P30281 | 3/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CCNH | P51946 | 1/20 | 0.42 |
| ▸ | NEK10 | Q6ZWH5 | 1/20 | 0.42 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.42 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25949368 | 0.81 | CDK2 (0.45) | KDM4EALDH1A1CDK4CCND1CDK2 | |
| SCHEMBL15492562 | 0.78 | KDM4E (0.54) | KDM4EALDH1A1MAPTPKMHRH3 | |
| SCHEMBL25949364 | 0.76 | POLB (0.51) | KDM4EALDH1A1MAPTCDK4CCND1 | |
| SCHEMBL611676 | 0.76 | KDM4E (0.53) | KDM4EALDH1A1MAPTPKMHRH3 | |
| SCHEMBL29963636 | 0.76 | KDM4E (0.53) | KDM4EALDH1A1MAPTPKMHRH3 | |
| SCHEMBL30664050 | 0.76 | KDM4E (0.53) | KDM4EALDH1A1MAPTPKMHRH3 | |
| SCHEMBL10255057 | 0.76 | KDM4E (0.53) | KDM4EALDH1A1MAPTPKMCDK4 | |
| SCHEMBL25949339 | 0.76 | CTSC (0.42) | ALDH1A1MAPTCDK4CCND1CDK2 | |
| SCHEMBL23108851 | 0.74 | HRH3 (0.51) | KDM4EALDH1A1MAPTPKMHRH3 | |
| SCHEMBL20148593 | 0.74 | OGA (0.62) | KDM4EALDH1A1MAPTPKMHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230248733-A1 | HIGHLY ACTIVE ANTI-NEOPLASTIC AND ANTI-PROLIFERATIVE AGENTS | G1 THERAPEUTICS, INC. (US) | 2023-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230248733-A1 | HIGHLY ACTIVE ANTI-NEOPLASTIC AND ANTI-PROLIFERATIVE AGENTS | MKI67, PCNA, HRAS | KDM4E 2602/4885ALDH1A1 1438/4885MAPT 4134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.