Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 13/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 8/20 | 0.42 |
| ▸ | METTL3 | Q86U44 | 6/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18572833 | 0.79 | PRMT5 (0.59) | PRMT5WDR77METTL3 | |
| SCHEMBL18572410 | 0.76 | PRMT5 (0.72) | PRMT5WDR77METTL3 | |
| SCHEMBL25951919 | 0.75 | PRMT5 (0.40) | PRMT5WDR77METTL3CYP3A4PDE10A | |
| SCHEMBL18571888 | 0.75 | PRMT5 (0.49) | PRMT5WDR77METTL3 | |
| SCHEMBL22684794 | 0.75 | PRMT5 (0.49) | PRMT5WDR77METTL3 | |
| SCHEMBL18571903 | 0.74 | PRMT5 (0.48) | PRMT5WDR77METTL3 | |
| SCHEMBL18571968 | 0.73 | PRMT5 (0.51) | PRMT5WDR77METTL3 | |
| SCHEMBL18571894 | 0.72 | PRMT5 (0.48) | PRMT5WDR77METTL3 | |
| SCHEMBL22684796 | 0.72 | PRMT5 (0.48) | PRMT5WDR77METTL3 | |
| SCHEMBL18572031 | 0.72 | PRMT5 (0.60) | PRMT5WDR77METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |