Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 8/20 | 0.66 |
| ▸ | INSR | P06213 | 4/20 | 0.66 |
| ▸ | MAP4K1 | Q92918 | 12/20 | 0.61 |
| ▸ | MET | P08581 | 2/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphine SCHEMBL25950706 | 0.90 | MAP4K1 (0.58) | ALKINSRMAP4K1 | |
| SCHEMBL25947598 | 0.89 | ALK (0.65) | ALKINSRMAP4K1MET | |
| Phosphine SCHEMBL25950701 | 0.88 | MAP4K1 (0.60) | ALKINSRMAP4K1MET | |
| Phosphine SCHEMBL25950711 | 0.88 | MAP4K1 (0.59) | ALKINSRMAP4K1 | |
| Phosphine SCHEMBL24870174 | 0.87 | MAP4K1 (0.64) | ALKINSRMAP4K1MET | |
| Phosphine SCHEMBL25950836 | 0.87 | MAP4K1 (0.63) | ALKINSRMAP4K1MET | |
| Phosphine SCHEMBL25950001 | 0.87 | ALK (0.61) | ALKINSRMAP4K1MET | |
| Phosphine SCHEMBL25950741 | 0.87 | MAP4K1 (0.58) | ALKINSRMAP4K1IGF1R | |
| SCHEMBL30446496 | 0.87 | MAP4K1 (0.77) | ALKINSRMAP4K1IGF1R | |
| SCHEMBL25338765 | 0.87 | MAP4K1 (0.77) | ALKINSRMAP4K1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230227483-A1 | PYRIMIDINE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | GLENMARK SPECIALITY S.A. (CH) | 2023-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227483-A1 | PYRIMIDINE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | MAP4K1, MAP3K4, MAP4K2 | ALK 2067/4885INSR 3399/4885MAP4K1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.