Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.31 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23892378 | 0.92 | PDPK1 (0.35) | PDPK1EPHA2BACE1 | |
| SCHEMBL23892620 | 0.91 | PDPK1 (0.35) | PDPK1EPHA2BACE1 | |
| SCHEMBL18571864 | 0.88 | BCHE (0.34) | BACE1 | |
| SCHEMBL23892497 | 0.88 | PRMT5 (0.32) | EPHA2ERBB2EPHB4 | |
| SCHEMBL23892224 | 0.88 | PDPK1 (0.33) | PDPK1BACE1RORC | |
| SCHEMBL23892588 | 0.86 | EPHA2 (0.31) | PDPK1EPHA2ERBB2EPHB4 | |
| SCHEMBL18571900 | 0.83 | PRMT5 (0.32) | PDPK1 | |
| SCHEMBL22685227 | 0.82 | PRMT5 (0.39) | — | |
| SCHEMBL23892636 | 0.82 | PRMT5 (0.39) | — | |
| SCHEMBL23892223 | 0.81 | PDPK1 (0.34) | PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |