Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 17/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 8/20 | 0.34 |
| ▸ | ABL2 | P42684 | 6/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 2/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18572864 | 0.79 | PRMT5 (0.42) | SRCMAP2K1 | |
| SCHEMBL18571891 | 0.79 | SRC (0.39) | SRCEGFRMAP2K1ABL1ABL2 | |
| SCHEMBL18572869 | 0.72 | PRMT5 (0.43) | — | |
| SCHEMBL18571815 | 0.68 | PRMT5 (0.53) | — | |
| SCHEMBL18572314 | 0.67 | PRMT5 (0.48) | — | |
| SCHEMBL18571889 | 0.67 | PRMT5 (0.39) | — | |
| SCHEMBL18572300 | 0.66 | PRMT5 (0.45) | — | |
| SCHEMBL18571895 | 0.65 | ENPP1 (0.37) | EGFRERBB2 | |
| SCHEMBL22002166 | 0.65 | ENPP1 (0.37) | EGFRERBB2 | |
| SCHEMBL22002269 | 0.65 | SRC (0.36) | SRCEGFRABL1ABL2ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |