Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 6/20 | 0.59 |
| ▸ | PARP1 | P09874 | 5/20 | 0.51 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.51 |
| ▸ | GUSB | P08236 | 5/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | RHEB | Q15382 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13298758 | 0.91 | TNKS (0.72) | TNKSPARP1TNKS2GUSBMMP2 | |
| SCHEMBL277488 | 0.79 | TNKS (0.51) | TNKSPARP1TNKS2GUSBCYP1A1 | |
| SCHEMBL259248 | 0.78 | TNKS (0.58) | TNKSPARP1TNKS2GUSBCYP1A1 | |
| SCHEMBL16965338 | 0.78 | TNKS (0.70) | TNKSPARP1TNKS2MMP2MMP9 | |
| SCHEMBL11099539 | 0.77 | GUSB (0.64) | TNKSPARP1TNKS2GUSBCYP1A1 | |
| SCHEMBL259533 | 0.76 | CHEK2 (0.61) | TNKSPARP1TNKS2GUSBMMP2 | |
| SCHEMBL259566 | 0.75 | TNKS (0.66) | TNKSPARP1TNKS2GUSBMMP2 | |
| SCHEMBL11388577 | 0.75 | CHEK2 (0.69) | TNKSPARP1TNKS2GUSBCYP1A2 | |
| SCHEMBL259557 | 0.75 | CYP1A1 (0.57) | TNKSPARP1TNKS2GUSBCYP1A1 | |
| SCHEMBL259520 | 0.73 | TNKS (0.68) | TNKSPARP1TNKS2GUSBMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067586-B2 | Fused heteroaryl derivatives | ASTELLAS PHARMA INC. (JP) | 2011-11-29 | — | — | US | disclosed |
| US-20100137584-A1 | FUSED HETEROARYL DERIVATIVES | HAYAKAWA MASAHIKO | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137584-A1 | FUSED HETEROARYL DERIVATIVES | PIK3CD, PIK3R3, PIK3C2A | TNKS 578/4885PARP1 1165/4885TNKS2 487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.