Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 7/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2593622 | 0.89 | KDR (0.41) | HDAC4HDAC2HDAC8KDRCLK4 | |
| SCHEMBL2587932 | 0.86 | KDR (0.39) | HDAC4HDAC2HDAC8KDRCLK4 | |
| SCHEMBL2591838 | 0.85 | HDAC4 (0.37) | HDAC4HDAC2HDAC8KDRCLK4 | |
| SCHEMBL2588166 | 0.85 | HDAC4 (0.39) | HDAC4HDAC2HDAC8KDRCLK4 | |
| SCHEMBL2590593 | 0.84 | HDAC4 (0.37) | HDAC4HDAC2HDAC8KDRCLK4 | |
| SCHEMBL2588602 | 0.84 | CLK4 (0.40) | HDAC4HDAC2HDAC8KDRCLK4 | |
| SCHEMBL2591611 | 0.84 | HDAC4 (0.39) | HDAC4HDAC2HDAC8KDRCLK4 | |
| SCHEMBL2589484 | 0.84 | KDR (0.38) | HDAC4HDAC2HDAC8KDRCLK4 | |
| SCHEMBL2591886 | 0.84 | KDR (0.38) | HDAC4HDAC2HDAC8KDRCLK4 | |
| SCHEMBL2593048 | 0.84 | KDR (0.36) | HDAC4HDAC2HDAC8KDRCLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-B1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2016-03-23 | — | — | EP | disclosed |
| EP-2563770-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | disclosed |