Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.49 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.45 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 6/20 | 0.44 |
| ▸ | CA1 | P00915 | 6/20 | 0.44 |
| ▸ | CA2 | P00918 | 6/20 | 0.44 |
| ▸ | CA4 | P22748 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27540555 | 1.00 | HDAC1 (0.51) | HDAC1HDAC3HDAC2NCOR2HDAC6 | |
| SCHEMBL16682328 | 0.95 | ADRB3 (0.44) | HDAC1HDAC3HDAC2NCOR2HDAC6 | |
| SCHEMBL579680 | 0.94 | LPAR1 (0.54) | HDAC1HDAC3HDAC2NCOR2HDAC6 | |
| SCHEMBL18067948 | 0.92 | ADRB3 (0.42) | HDAC1HDAC3HDAC2NCOR2HDAC6 | |
| SCHEMBL9823156 | 0.92 | HDAC1 (0.54) | HDAC1HDAC3HDAC2NCOR2HDAC6 | |
| SCHEMBL3151994 | 0.91 | HDAC3 (0.59) | HDAC1HDAC3HDAC2NCOR2MAOB | |
| SCHEMBL3695642 | 0.88 | HDAC1 (0.55) | HDAC1HDAC3HDAC2NCOR2HDAC6 | |
| SCHEMBL580233 | 0.88 | HDAC1 (0.55) | HDAC1HDAC3HDAC2NCOR2HDAC6 | |
| SCHEMBL1798901 | 0.88 | HDAC1 (0.52) | HDAC1HDAC3HDAC2NCOR2HDAC6 | |
| SCHEMBL18067962 | 0.88 | HDAC3 (0.46) | HDAC1HDAC3HDAC2NCOR2CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569290-A2 | PHARMACEUTICAL COMPOUNDS | Sentinel Oncology Limited (GB) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011141716-A2 | PHARMACEUTICAL COMPOUNDS | SENTINEL ONCOLOGY LIMITED (GB) | 2011-11-17 | — | — | WO | disclosed |