Sugi Predict

Sugi Predict / Compounds / SCHEMBL25954808

SCHEMBL25954808

SCHEMBL25954808

C/C=C\C=C(CCC)\C(=N/c1nc2cc(OC[C@H]3C[C@@H](n4ccc5c(OC)ncnc54)[C@@H]4OC(C)(C)O[C@H]34)ccc2cc1Cl)c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ METTL3 Q86U44 4/20 0.37
▸ PRMT5 O14744 13/20 0.35
▸ WDR77 Q9BQA1 11/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18572097 0.88 PRMT5 (0.40) METTL3PRMT5WDR77
SCHEMBL18572093 0.88 PRMT5 (0.40) METTL3PRMT5WDR77
SCHEMBL18572005 0.81 PRMT5 (0.41) METTL3PRMT5WDR77
SCHEMBL18571897 0.73 PRMT5 (0.46) METTL3PRMT5WDR77
SCHEMBL18571941 0.72 PRMT5 (0.58) METTL3PRMT5WDR77
SCHEMBL23892678 0.71 PRMT5 (0.36) METTL3PRMT5WDR77
SCHEMBL22684518 0.71 PRMT5 (0.36) METTL3PRMT5WDR77
SCHEMBL23892595 0.70 PRMT5 (0.36) METTL3PRMT5WDR77
SCHEMBL22002119 0.70 PRMT5 (0.40) METTL3PRMT5WDR77
SCHEMBL18572070 0.69 PRMT5 (0.53) METTL3PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4219496-A1 NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS JANSSEN Pharmaceutica NV (BE) 2023-08-02 — — EP disclosed
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