SCHEMBL25955239

SCHEMBL25955239

CCOC(=O)c1cccn1COC

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 8/20 0.45
TSHR P16473 1/20 0.44
CA12 O43570 2/20 0.42
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42
CA7 P43166 2/20 0.42
CA9 Q16790 2/20 0.42
CA14 Q9ULX7 2/20 0.42
CYP1A2 P05177 1/20 0.41
HPGD P15428 1/20 0.41
HTT P42858 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.40
ALDH1A1 P00352 2/20 0.40
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40
HSD17B10 Q99714 1/20 0.39
ESR1 P03372 1/20 0.39
ESR2 Q92731 1/20 0.39
MAPK1 P28482 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13541632 0.85 TSHR (0.48) EPHX2TSHRCA12CA1CA2
SCHEMBL17574712 0.82 TSHR (0.46) EPHX2TSHRCA12CA1CA2
SCHEMBL29225365 0.82 TSHR (0.46) EPHX2TSHRCA12CA1CA2
SCHEMBL30829444 0.82 TSHR (0.46) EPHX2TSHRCA12CA1CA2
SCHEMBL29225350 0.79 EPHX2 (0.44) EPHX2TSHRCA12CA1CA2
SCHEMBL17574715 0.79 EPHX2 (0.44) EPHX2TSHRCA12CA1CA2
SCHEMBL3016395 0.79 EPHX2 (0.44) EPHX2TSHRCA12CA1CA2
SCHEMBL3011416 0.78 NPC1 (0.44) EPHX2TSHRCA12CA1CA2
SCHEMBL15848888 0.78 EPHX2 (0.57) EPHX2TSHRSMN1; SMN2ALDH1A1MAPT
SCHEMBL3024871 0.77 EPHX2 (0.42) EPHX2TSHRCA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023144126-A1 CATALYST COMPOSITION INEOS EUROPE AG (CH) 2023-08-03 WO disclosed